Investigating the Applicability of qALPV Modeling to ICU Models for Glycaemic Control

摘要

Maintenance of glucose levels in intensive care unit (ICU) patients via control of insulin inputsis currently an active research field. Different published models that address this problem are analysedfrom control theory point of view. This paper analyzes the three most used ICU metabolic system modelsin the literature, two of which have been validated in clinical trials or alternate clinical use. Globalcontrol theoretical characteristics are determined using nonlinear analysis. Quasi affine linear parametervarying (qALPV) modeling methodology is then investigated for further robust nonlinear model basedcontrol.