Synthesis of Novel Homo-N-Nucleoside Analogs Composed of a Homo-1,4-Dioxane Sugar Analog and Substituted 1,3,5-Triazine Base Equivalents

摘要

Enantioselective syntheses from dimethyl tartrate of 1,3,5-triazine homo-Nnucleosideanalogs, containing a 1,4-dioxane moiety replacing the sugar unit in naturalnucleosides, were accomplished. The triazine heterocycle in the nucleoside analogs wasfurther substituted with combinations of NH2, OH and Cl in the 2,4-triazine positions.