Mechanistic Comparison between Gastric Bypass vs. Duodenal Switch with Sleeve Gastrectomy in Rat Models

摘要

Background: Both gastric bypass (GB) and duodenal switch with sleeve gastrectomy (DS) have been widely used as bariatricsurgeries, and DS appears to be superior to GB. The aim of this study was to better understand the mechanisms leading tobody weight loss by comparing these two procedures in experimental models of rats.Methods: Animals were subjected to GB, DS or laparotomy (controls), and monitored by an open-circuit indirect calorimetercomposed of comprehensive laboratory animal monitoring system and adiabatic bomb calorimeter.Results: Body weight loss was greater after DS than GB. Food intake was reduced after DS but not GB. Energy expenditurewas increased after either GB or DS. Fecal energy content was increased after DS but not GB.Conclusion: GB induced body weight loss by increasing energy expenditure, whereas DS induced greater body weight lossby reducing food intake, increasing energy expenditure and causing malabsorption in rat models.