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Synthesis and characterization of biodegradable hydrogels for oral delivery of 5-fluorouracil targeted to colon:screening with preliminary in vivo studies

机译:口服递送5-氟尿嘧啶靶向结肠的生物可降解水凝胶的合成与表征:体内初步研究的筛选

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摘要

In this communication, we developed a thermally stable, biocompatible, and colonically degradable hydrogel-based device [pectin-co-poly(MAA)] for oral delivery of 5-fluorouracil (5-FU) to treat colon cancer with minimal upper gastrointestinal invasion. Toward this end, ethylene glycol dimethacrylate (EGDMA) cross-linked hydrogels of pectin were synthesized. Methacrylic acid (MAA) was grafted to impart pH-responsive character, whereas benzoyl peroxide (BPO) was applied for simultaneous grafting and cross-linking polymerization. The hydrogels were characterized by Fourier transform infrared , thermogravimetric analysis, differential scanning calorimetry, and X-ray diffractometry. Scanning electron microscopic photographs were taken to analyze the surface morphology. Swelling behavior was analyzed to assess better performance of biodegradable hydrogels for optimized loading and release of the drug targeted to the colon. Gel fraction, swelling ratio, diffusion coefficient, drug loading, and cumulative release increased with an increase of pectin ratio and decreased with an increase of MAA and EGDMA ratio. Strategically, hydrogels with higher amounts of pectin were prepared for complete degradation in the colon. Our investigations indicate that pectin-co-poly(MAA) hydrogel is a suitable delivery system developed for oral delivery of the drug targeted to the colon.
机译:在此交流中,我们开发了一种热稳定,生物相容且可结肠降解的基于水凝胶的装置[果胶-共聚(MAA)],用于口服递送5-氟尿嘧啶(5-FU),以最小的上消化道侵袭治疗结肠癌。为此,合成了果胶的乙二醇二甲基丙烯酸酯(EGDMA)交联水凝胶。接枝甲基丙烯酸(MAA)以赋予pH响应特性,而过氧化苯甲酰(BPO)用于同时接枝和交联聚合。通过傅立叶变换红外,热重分析,差示扫描量热法和X射线衍射法表征水凝胶。拍摄扫描电子显微镜照片以分析表面形态。分析了溶胀行为,以评估可生物降解水凝胶对靶向结肠的药物的最佳装载和释放的更好性能。胶凝率,溶胀率,扩散系数,载药量和累积释放量随果胶比的增加而增加,随MAA和EGDMA比的增加而降低。从战略上讲,要在结肠中完全降解制备具有更高果胶含量的水凝胶。我们的研究表明,果胶共聚(MAA)水凝胶是一种适合口服给药靶向结肠的药物的合适给药系统。

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