Final Report on the Developmental Toxicity of Mono(2-Ethylhexyl)Phthalate (CASNO. 4376-20-9) in CD-1-Swiss Mice. Volume 1. Final Study Report and Appendix

摘要

Mono(2-ethylhexyl)phthalate (MEHP) and 2-ethylhexanol (2-EH) are metabolites ofdi(2-ethylhexyl)phthalate (DEHP), a widely used phthalate ester plasticizer. MEHP (0%, 0.017%, 0.035%, 0.070% or 0.140% in feed) was provided on gestational days (gd) 0 to 17 to timed-pregnant Swiss (CD-1) mice (25-27/group). Average doses were 0, 35, 73, 134 or 269 mg MEHP/kg/day, respectively. At sacrifice (gd 17), the number of resorptions, and dead or live fetuses were recorded. Live or dead fetuses were weighed. Live fetuses were sexed and examined for external, visceral and skeletal malformations. Maternal and developmental effects of MEHP exposure throughout gestation were qualitatively similar to those previously reported for DEHP at approximately equimolar doses administered under comparable experimental conditions (Tyl et al., 1988). The data indicate that MEHP plays a significant role in the expression of DEHP-induced maternal and developmental toxicity.