Toxicology and Carcinogenesis Studies of C.I. Acid Red 114 (CAS No. 6459-94-5) in F344/N Rats (Drinking Water Studies).

摘要

Toxicology and carcinogenesis studies were conducted by administering desalted, industrial grade C. I. Acid Red 114 in drinking water to groups of F344/N rats of each sex for 104 weeks. Male rats received 0, 70, 150, or 300 ppm C. I. Acid Red 114, female rats received 0, 150, 300, or 600 ppm. Under the conditions of the 2-year drinking water studies, there was clear evidence of carcinogenic activity of C. I. Acid Red 114 for male F344/N rats, as indicated by benign and malignant neoplasms of the skin, Zymbal's gland, and liver. Increased incidences of neoplasms of the oral cavity epithelium, adrenal gland, and lung may have been related to chemical administration. There was clear evidence of carcinogenic activity for female F344/N rats as indicated by benign and malignant neoplasms of the skin, Zymbal's gland, clitoral gland, liver, oral cavity epithelium, small and large intestines, and lung. Increased incidences of mononuclear cell leukemia, mammary gland adenocarcinoma, and adrenal gland pheochromocytomas may have been related to chemical administration.