NIOSH Comments to DOL on the Occupational Safety and Health Administration's Reopening of the Rulemaking Record for the Proposed Rule on Occupational Exposure to Cadmium by R. W. Niemeier, November 4, 1991.

摘要

The testimony concerns the reopening of the rulemaking record on cadmium (7440439) by OSHA in an effort to allow public comment on new toxicologic data regarding solubility, bioavailability, toxicity, carcinogenicity, and potency of cadmium-sulfide (1306236) relative to other cadmium compounds. NIOSH agrees that cadmium-sulfide has been shown to be tumorigenic in rats by intratracheal installation; that cadmium-sulfide is carcinogenic in rats following intraperitoneal injection; and that short term studies of cadmium-sulfide pulmonary bioavailability demonstrate that long term bioavailability exists for the compound, even though it is lower than the bioavailabilities for cadmium-oxide (1306190) and cadmium-sulfate (10124364). NIOSH agrees that further studies on the carcinogenicity and bioavailability of cadmium-sulfide are warranted, but that the data available at this time do not offer a clear basis for treating the compound differently than any other cadmium compound from a regulatory standpoint.