Quantitative Genetic Activity Graphical Profiles for Use in Chemical Evaluation

摘要

A graphic approach termed a Genetic Activity Profile (GAP) has been developed todisplay a matrix of data on the genetic and related effects of selected chemical agents. The profiles provide a visual overview of the quantitative (doses) and qualitative (test results) data for each chemical. Either the lowest effective dose (LED) or highest ineffective dose (HID) is recorded for each agent and bioassay. Up to 200 different test systems are represented across the GAP. Bioassay systems are organized according to the phylogeny of the test organisms and the endpoints of genetic activity. The methodology for the production and evaluation of genetic activity profiles has been developed in collaboration with the International Agency for Research on Cancer (IARC). Data on individual chemicals has been compiled by IARC and by the U.S. Environmental Protection Agency (EPA). Data are available on 299 compounds selected from volumes 1-50 of the IARC Monographs and on 115 compounds identified as Superfund Priority Substances. Structurally similar compounds frequently display qualitatively and quantitatively similar profiles of genetic activity. Through the examination of the patterns of GAPs of pairs and groups of chemicals, it is possible to make more informed decisions regarding the selection of test batteries to be used in the evaluation of chemical analogs.