Inhalation Toxicology of Red and Violet Mixtures. Chamber Concentration andParticle Size Distribution Report

摘要

An inhalation exposure facility was developed at the U.S. EPA, RTP, NC to conductinhalation exposures of rodents and guinea pigs to dye mixtures used by the U.S. Army in the manufacture of smoke munitions. Initially, an evaluation of the prototype chamber aerosol homogeneity was conducted to determine the uniformity and reproducibility of the concentration and particle size of dye aerosol throughout the breathing zone of the test animals (Davies, et al.). The three dyes, DR11, SR1, and DB3, were chemically analyzed for purity and optically examined for size and shape. All pure dyes appeared to be stable at room temperature except DB3, which decomposes if not stored at 4 C. The particle size ranges varied for each pure dye and structures were either amorphous (azo dye) or crystalline (anthraquinone dyes). The bulk red and violet dye mixtures were analyzed for composition. The chemical analysis of the relative composition of each dye mixture, collected by cascade impactor sampling, revealed fractionation of the mixtures into component dyes.