Gene Expression in Pre-Implantation Mammalian Embryos

摘要

The pre-implantation mammalian embryo is initially under the control of maternalinformational macromolecules that are accumulated during oogenesis. Subsequently, the genetic program of development becomes dependent upon new transcription derived from activation of the embryonic genome. Several embryonic transcripts including those that encode growth factors, cell junction components and plasma membrane ion transporters are required for normal progression of the embryo to the blastocyst stage. The pattern of genes expressed and the overall program of development is subject to the influences of genomic imprinting as well as external influences encountered by the embryo within the maternal reproductive tract. (Copyright (c) 1992 Elsevier Science Publishers B.V.)