Final Report on the Reproductive Toxicity of Pesticide/Fertilizer Mixture 2: Reproduction and Fertility Assessment in Swiss CD-1 Mice When Administered via Drinking Water

摘要

Pesticide/Fertilizer Mixture II (PFM II) is composed of six pesticides and represents a real-life scenario of groundwater contamination in California. PFM II in water was tested for its effects on fertility and reproduction in Swiss CD-1 mice according to the Continuous Breeding Protocol. Male and female mice (F0) were continuously exposed for a 7-day precohabitation and a 98-day cohabitation period (Task 2). The F1 pups from the final litter in the control, 10 and 100X groups were weaned for second generation studies. Kidney/adrenal weights were approximately 10% higher than controls in F1 10X-treated males and females and 100X-treated females. Absolute seminal vesicle weight as well as seminal vesicle-to-body weight ratio significantly decreased (ca. 11%) in the 100X dose group. PFM II was not a reproductive toxicant in Swiss CD-1 mice at the dose levels tested.