Initial Submission: Letter from Eastman Kodak Company to USEPA regarding Toxicity Studies of 5-Methyl-2-Hexanone and Other Chemicals with Attachments and Cover Letter dated 09/28/1992

摘要

The oral LD50 of this compound when administered by gavage to rats and mice was estimated to be greater than 3200 mg/k5 b.v. Skin irritation vas slight with some desquamation observed following continuous compound contact for 24 hours to the devilated 6uinea pig abdomen under an occluded patch. Repeated daily application to the clipped backs of guinea pigs over a ten day period exacerbated the irritation observed after a single application with two of five animals tested developing slight to moderate erythema and all animals developing dry skin and cracked eschars. A weak allergic response was observed in one of five guinea pigs tested using a standard sensitization potential test. No sensitization response was observed in the remaining four animals. Ocular irritation was slight in three rabbit eyes exposed to the compound. Adnexal staining was seen in two of three eyes. Prompt irrigation in three additional eyes had a palliative effect. Rats were given either single or repeated inhalation exposures to the compound which was vaporized, diluted with air, directed to a 20 liter glass bell jar, and monitored by infrared spectroscopy. In the single exposure inhalation study, rats received single six hour exposures to vapor concentrations ranging from about 800 to 6000 ppm. Animals were observed over a 16 day period. The LC50 was estimated to be 3813 ppm with one death occurring at 3207 ppm. Rye irritation, reduced respiratory rate, narcosis and deaths occurred during the exposure period only. No unusual signs were observed in animals surriving exposures. Weight gains of surviving animals were normal.