NTP Technical Report on Toxicity Studies of Black Newsprint Inks Administered Topically to F344/N Rats and C3H Mice.

摘要

Toxicity studies were conducted by applying black newsprint inks or mineral oils to clipped skin of the dorsal interscapular area of C3H mice and F344/N rats of both sexes, to determine systemic and local effects. Results of these studies indicate that topical administration of black newsprint inks and mineral oils produces local toxicity at the site of application in mice; toxic effects on the skin in the species are consistent with those of a primary cutaneous irritant. In rats, possible evidence for toxicity was limited to decreased body weight gains in females treated with letterpress ink formulations. In genetic toxicity studies, letterpress and offset newsprint ink composite mixtures were each mutagenic in Salmonella typhimurium strains TA98 and TA100 when tested in a preincubation protocol with added hamster liver S9. With rat liver S9, results for both inks were positive in strain TA98 and negative in strain TA100. Neither type of ink was mutagenic in the absence of S9 activation.