Dose Response of 'Cryptosporidium parvum' in Outbred Neonatal CD-1 Mice

摘要

Cryptosporidium parvum infectivity in a neonatal CD-1 mouse model was used todetermine the dose needed to infect 50% of the population. The 50% infective dose was estimated to be 79 oocysts. It was observed that a mean oral inoculum of 23 oocysts produced infection in 2 of 25 neonatal mice 7 days postinoculation. All animals became infected when the mean oral dose exceeded 310 oocysts per animal. The dose response of C. parvum was modeled with a logit dose-response model suitable for use in water disinfection studies. (Copyright (c) 1993 American Society for Microbiology.)