NTP Technical Report on Toxicity of Tetrachlorophthalic Anhydride (CAS No. 117-08-8) Administered by Gavage to F344/N Rats and B6C3F1 Mice

摘要

Tetrachlorophthalic anhydride (TCPA) is primarily used as a flame retardant inplastics. Several cases of occupational asthma attributed to TCPA exposure have been reported in the literature. Toxicology studies were conducted by administering TCPA by oral gavage to F344/N rats and B6C3F1 mice for 13 weeks. Evaluations included histopathology, clinical pathology, and analyses of reproductive system parameters. The genetic toxicity of TCPA was assessed with in vitro tests of mutagenicity in Salmonella typhimurium and induction of sister chromatid exchanges and chromosomal aberrations in Chinese hamster ovary cells, and in mouse bone marrow cells following in vivo exposure. The ability of TCPA to induce sex-linked recessive lethal mutations was also studied.