NTP Technical Report on Toxicity Studies of 2-Chloronitrobenzene and 4-Chloronitrobenzene (CAS Nos. 88-73-3 and 100-00-5) Administered by Inhalation to F344/N Rats and B6C3F1 Mice

摘要

2-Chloronitrobenzene and 4-chloronitrobenzene are oily yellow solids that areused primarily as chemical intermediates in the production of dyes, lumber preservatives, drugs, and photographic chemicals. Toxicity studies of 2-chloronitrobenzene and 4-chloronitrobenzene were performed by exposing male and female F344/N rats and B6C3F1 mice to the chemicals by whole-body inhalation 6 hours per day, 5 days per week, for 2 weeks or 13 weeks. Animals were evaluated for histopathology, clinical chemistry (rats), hematology (rats), and reproductive system effects. In separate studies, the dermal absorption of the chemicals was compared, and the absorption, distribution, metabolism, and excretion were partially characterized following oral administration to male F344/N rats. 2-Chloronitrobenzene and 4-chloronitrobenzene were also administered orally to CD-1 Swiss mice for evaluation of reproductive and developmental toxicity. Genetic effects were evaluated in Salmonella typhimurium, in Chinese hamster ovary cells, and in Drosophila melanogaster.