Sigma, PCP, and NMDA Receptors

摘要

;Contents: Phencyclidine Receptor Binding as a Probe of NMDA ReceptorFunctioning: Implications of Drug Abuse Research; Pharmacologic Regulation of the NMDA Receptor-Ionophore Complex; Pharmacologic Characterizations of sigma Receptors; Studies of sigma Receptors and Metabolic Responses to sigma Ligands in the Brain; Sigma Receptors and Signaling Transduction: Negative Modulation of Signaling Through Phosphoinositide-Linked Receptor Systems; Sigma and Phencyclidine Receptors in the Brain-Endocrine-Immune Axis; A Role for sigma Binding in the Antipsychotic Profile of BMY 14802; Molecular Biology of PCP and NMDA Receptors; Excitatory Amino Acid Neurotoxicity in the Developing Brain; Isolation and Characterization of an Endogenous Ligand for the PCP and sigma Receptors From Procine, Rat, and Human Tissue; Summary and Future Directions.