Effect of 5-Azacytidine Administration during Very Early Pregnancy

机译：5-氮杂胞苷在极早期妊娠中的作用

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The chemotherapeutic agent 5-azacytidine (5AZ) is cytotoxic via nucleic acidhypomethylation. Malformations and embryo-lethality result when rats or mice are exposed to 5AZ on any of Days 9 through 12 of pregnancy. To investigate the

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作者
Cummings, A. M.;
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年度 1994
页码 p.1-7
总页数 7
原文格式 PDF
正文语种 eng
中图分类工业技术;
关键词
Azacytidine; Pregnancy; Teratogens; Toxicity; Pregnancy outcome; Body weight; Congenital abnormalities; Preimplantation phase; Postimplantation phase; Fetus; Microphthalmos; Dose-response relationships; Reprints;

机译：氮杂胞苷;妊娠;致畸物;毒性;妊娠结局;体重;先天性异常;植入前期;植入后期;胎儿;微小脑;剂量 - 反应关系;重印;

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2. Effects of d-cloprostenol administrations with 7.5 and 11.5-day intervals between administrations on pregnancy rates after artificial insemination in estrous cyclic dairy goats [J] . Bonato G. C., Maia A. L. R. S., Cortes L. R., Animal Reproduction Science . 2019,第期

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3. High Throughput Screen Identifies the DNMT1 (DNA Methyltransferase-1) Inhibitor, 5-Azacytidine, as a Potent Inducer of PTEN (Phosphatase and Tensin Homolog) Central Role for PTEN in 5-Azacytidine Protection Against Pathological Vascular Remodeling [J] . Strand Keith A., Lu Sizhao, Mutryn Marie F., Arteriosclerosis, thrombosis, and vascular biology . 2020,第8期

机译：高通量筛网识别DNMT1（DNA甲基转移酶-1）抑制剂，5-氮杂胞苷，作为PTEN（磷酸酶和牙素同源物）的有效诱导剂，用于PTEN在5-氮杂胞苷保护免受病理血管改造的情况下
4. Administration of human chorionic gonadotropin in early pregnancy increasesovarian activity in sows [C] . J. Seyfang, T. Y. Chen, P. Langendijk, Biennial Conference of the Australasian Pig Science Association . 2015

机译：孕早期妊娠早期促进人绒毛膜促性腺激素
5. The transcirptomic and methylomic changes caused by subtoxic doses of 5-Azacytidine and 5-Aza-2'-deoxycitide. [D] . Smit, Evelyn. 2014

机译：亚毒性剂量的5-氮杂胞苷和5-Aza-2'-脱氧胞苷引起的经皮和甲组学变化。
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机译：在非人类原始模型中静脉鼻内和鞘内给药后5-氮杂胞苷的PCM-10血浆和脑脊髓液动力学
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机译：在非人灵长类动物模型中静脉内，鼻内和鞘内给药后5-氮杂胞苷的PCM-10plasma和脑脊液药代动力学

Effect of 5-Azacytidine Administration during Very Early Pregnancy

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