Aspen Cancer Conference (8th): Molecular Mechanisms of Toxicity in Relation tothe Genetics of Animal and Human Neoplasia. Held on July 17-22, 1993

摘要

Cancers arise as a consequence of the interactions between environmental factorsand specific genes. The environmental factors range from the ubiquitous, such as sunlight, to the highly specific, such as occupational exposures to particular chemicals. The genes with which these factors interact include those that influence the metabolic fate and distribution of specific chemicals as well as those that may be targets for the action of chemicals. Since the magnitude and duration of exposure are critical factors in determining the consequences of chemical-gene interactions, the toxicological properties of environmental carcinogens are also significant determinants. The Eighth Aspen Cancer Conference, held on July 17, 22, 1993, assembled a diverse group of distinguished investigators whose interests and expertise encompass these issues. The topics were presented and discussed in eight sessions, the highlights of which are summarized herein. (Copyright (c) 1994 Wiley-Liss, Inc.)