Comparative Toxicity of Azinphos-Methyl to House Mice, Laboratory Mice, DeerMice, and Gray-Tailed Voles

摘要

The authors conducted a laboratory toxicity study on house mice and laboratorymice, gray-tailed voles, and deer mice as part of a comprehensive laboratory and field study to field-validate laboratory-based risk assessment of argichemicals. The single dose oral LD50 for the organophosphorus insecticide azinphos-methyl was 10, 11, 32, 48 mg/kg body mass in wild house mice, laboratory mice, gray-tailed voles, and deer mice, respectively. The authors conclude that (1) laboratory mice were not representative of deer mice or gray-tailed voles with respect to sensitivity to the pesticide, but provided a conservative estimates for risk assessment; (2) 5-d dietary LC50 tests provide substantially higher estimates of toxicity to rodents than do 10-d test; and (3) ChE depression of 45 to 50% was lethal.