Cardiopulmonary Health Effects: Toxicity of Semi-Volatile and Non-Volatile Components of PM.

摘要

The goal of this project was to determine whether or not the toxicity of ultrafine (UFP; particles . 0.18 Em aerodynamic diameter) particles depends on the concentration and composition of semi-volatile and non-volatile fractions of the PM. We tested the hypothesis that adverse effects of exposure to these UFP, which are primarily emitted by combustion sources and are highly enriched in semi-volatile components, will be significantly attenuated by removal of those components from the aerosol. We used a unique mobile in vivo rodent exposure system in combination with a particle concentrator and thermal denuder to study the cardiopulmonary effects of UFP, before and after the removal of the semi-volatile components.