Toxicity of an Anthraquinone Violet Dye Mixture Following Inhalation Exposure,Intratracheal Instillation, or Gavage

摘要

Anthraquinone dyes in a variety of functions from drug formulations fabriccolorative to area markings as might be used of the military. The effects of a prototype violet dye mixture (VDM) consisting of: Disperse Red 11 (DR11) 1,4-diamino-2-methoxy-anthraquinone and Disperse Blue 3 (DB3) 1-methylamino-4-hydroxyethylamino-anthraquinone on F344 male and females rats have been investigated. Acute inhalation exposures (6 hr) to VDM ranged from 1000 mg/cu m, with an additional exposure to 40 mg/cu m 6 hr/day for 5 days (MMAD's ranged from 3.37 to 4.95 micrometers). Histopathology and/or liver function was evaluated at 0, 3 and 7 days post. Unexpected lethality due to severe liver damage was observed with acute exposures of > or = to 300 mg/cu m and in the 5 day 40 mg/cu m exposure. In addition, nasal olfactory epithelium exhibited degeneration and