Novel Method Identifies Potential Key Pathway in Arsenic-Induced Birth Defects. Research Brief 221.

摘要

Blocking the glucocorticoid receptor (GR) pathway in a chick embryo model prevents structural birth defects induced by arsenic, according to a 2013 NIEHS-funded study at the University of North Carolina at Chapel Hill Superfund Research Program (UNC SRP). The laboratory study was performed after computationally predicting the association between the GR pathway and metal-induced birth defects with a novel approach to identify targeted biological pathways.