Final Report on the Developmental Toxicity of 8-Methoxypsoralen (CAS No. 298-81-7) in New Zealand White (NZW) Rabbits

摘要

8-Methoxypsoralen (MOXY) forms monoadducts and crosslinks with DNA in conjunctionwith ultraviolet light irradiation. This forms the basis of its clinical use as an antiproliferative agent in hyperproliferative skin diseases, but MOXY may also be mutagenic in the absence of light. Because of MOXY's potential to affect rapidly dividing cells, it may pose a threat to the developing conceptus. Accordingly, MOXY (0, 40, 80, or 105 mg/kg/day) was administered by gavage to pregnant New Zealand white rabbits during the period of major organogenesis (gd 6-19). Maternal clinical signs, body weight, and food consumption were monitored from gd 0 to gd 30. On gd 30, fetuses were removed from the does and examined for evidence of developmental toxicity. MOXY, at doses which cause minor maternal toxicity, does not affect fetal growth, viability, or morphological development.