Supercritical Crystallization: The RESS-Process and the GAS-Process

摘要

This Doctoral Ph.D. thesis describes the development of two novel crystallizationprocesses utilizing supercritical fluids either as a solvent, the RESS-process, or as an anti-solvent, the GAS-process. In th RESS-process precipitation ofthe solute is performed by expansion of the solution over a nozzle to produce ultra-fine, monodisperse particles without any solvent inclusions. In the GAS-process a high pressure gas is dissolved into the liquid phase solvent, where it causes a volumetric expansion of this liquid solvent and lowers the equilibrium solubility. Particle size, particle size distribution and other particle characteristics such as their shape, internal structure and the residual amount of solvent in the particles are expected to be influenced by the liquid phase expansion profile.