NTP Technical Report on Toxicity Studies of Sodium Selenate and Sodium Selenite(Cas No. 13410-01-0 and 10102-18-8) Administered in Drinking Water to F344/N Rats and B6C3F1 Mice

摘要

Sodium selenate and sodium selenite are used as supplements to poultry andlivestock feed to promote growth and prevent selenium deficiency diseases. Both compounds have been found in chemical waste sites. Thirteen-week toxicity studies were conducted by administering the chemicals to groups of male and female F344/N rats and B6C3F1 mice in drinking water. Animals were evaluated for hematology, clinical chemistry, urinalysis (rats only), histopathology, and reproductive system effects. Based on mortality in rats, body weight depression, and renal lesions, sodium selenate and sodium selenite were more toxic to rats than to mice. These chemicals caused increases in estrous cycle length in rats; sodium selenite also cause an increase in estrous cycle length in mice.