NTP Technical Report on Toxicity Studies of Urethane in Drinking Water andUrethane in 5% Ethanol Administered to F344/N Rats and B6C3F1 Mice

摘要

Urethane, a byproduct of fermentation found in alcoholic beverages, iscarcinogenic in rodents and is classified by the International Agency for Research on Cancer as a possible human carcinogen. The United States Food and Drug Administration nominated urethane for study because of the widespread exposure of humans through the consumption of fermented foods and beverages and because of a lack of adequate dose-response data about the carcinogenicity of urethane with and without the coadministration of ethanol. Comparative studies of urethane in drinking water and in 5% ethanol were conducted to investigate possible effects of ethanol on urethane toxicity. Toxicokinetic studies of urethane in drinking water and in 5% ethanol and genetic toxicity studies of urethane in vivo and in vitro were also conducted.