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Practical Concepts for Dose Selection in Chronic Toxicity and CarcinogenicityStudies in Rodents

机译：啮齿类动物慢性毒性和致癌性研究中剂量选择的实用概念

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The process for selecting the Highest Dose to be Tested (HDT) in chronic toxicityand carcinogenicity studies in rodents has been reviewed. Current scientific and regulatory guidelines largely agree on general principles but differ or conflict on practical guidance. This arises from various interpretations of the meaning of

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年度 1996
页码 p.1-63
总页数 63
原文格式 PDF
正文语种 eng
中图分类工业技术;
关键词
Toxicity; Dose-response relationship; Carcinogenesis; Rats; Laboratory animals; Toxicokinetics; Regulations; Guidelines;

机译：毒性;剂量 - 反应关系;癌变;大鼠;实验室动物;毒物动力学;法规;指南;

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专利

1. Issues in the design and interpretation of chronic toxicity and carcinogenicity studies in rodents: approaches to dose selection. [J] . Rhomberg LR, Baetcke K, Blancato J, Critical reviews in toxicology . 2007,第9期

机译：啮齿类动物慢性毒性和致癌性研究的设计和解释中的问题：选择剂量的方法。
2. Role of kinetically derived maximum dose (KMD) in top-dose selection for chronic repeated dose toxicity studies [J] . Domoradzki J., Corvaro M., Terry C. Toxicology Letters: An International Journal Providing a Forum for Original and Pertinent Contributions in Toxicology Research . 2019,第期

机译：动力学衍生的最大剂量（KMD）在慢性重复剂量研究中的顶剂选择中的作用
3. Principles for the selection of doses in chronic rodent bioassays [J] . Jeffery A. Foran Environmental Health Perspectives . 1997,第1期

机译：慢性啮齿动物生物测定中选择剂量的原则
4. Differential Genes Expression Analysis of Chronic Toxicity of Organophosphorus Pesticide at Low Dose Exposure Using Oligonucleotide Microarrays [C] . ZHONG Wei-jian, YING Xian-ping, MA Guo-yun, International Academic Conference on Environmeatal amp; Occupational Medicine; 20041110-12; Shanghai(CN) . 2004

机译：寡核苷酸微阵列在低剂量有机磷农药慢性毒性差异基因表达分析
5. The application of a passive dosing system for determining zebrafish early life stage toxicity of hydrocarbons for use in calibrating a predictive model to acute and chronic endpoints. [D] . Butler, Joshua D. 2013

机译：被动加药系统在确定斑马鱼碳氢化合物生命早期毒性方面的应用，可用于校准对急性和慢性终点的预测模型。
6. Principles for the selection of doses in chronic rodent bioassays. ILSI Risk Science Working Group on Dose Selection. [O] . J A Foran 1997

机译：在慢性啮齿动物生物测定中选择剂量的原则。 ILSI风险科学剂量选择工作组。
7. Principles for the selection of doses in chronic rodent bioassays. ILSI Risk Science Working Group on Dose Selection. [O] . J A Foran 1997

机译：慢性啮齿动物生物测定中选择剂量的原理。 ILSI风险科学工作组剂量选择。
8. The Toxicity of Single Doses of N-Nitrodimethylamine in Rodents. [R] . Andersen, M. E., Jenkins, L. J. 1978

机译：单剂量N-硝基二甲胺对啮齿动物的毒性。

Practical Concepts for Dose Selection in Chronic Toxicity and CarcinogenicityStudies in Rodents

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