Cartilage Marker Detection in Traumatic Knee Injury

摘要

This investigator proposes to develop a sensitive and comprehensive immunoassayfor the detection of collagen type II in synovial fluid of patients with traumatic knee injury. It is anticipated that there will be correlation between the presence and level of collagen II in synovial fluid and the extent of traumatic cartilage damage. This proposal will not only facilitate the development of a diagnostic test to evaluate and monitor traumatic knee injury, but will also test the hypothesis that release of collagen type II into the synovial fluid may induce the local production of autoantibodies to collagen type II and initiate post-traumatic arthritis.