Support: Styrene-104 Week Repeat Dose Inhalation Combined Toxicity/Carcinogenicity Study in Mice with Cover Letter dated 07/22/1998

摘要

This study was performed to assess the chronic toxicity and carcinogenic potential of styrene, administered by whole-body inhalation exposure to CD-1 mice over a period of 2 years. Exposure was carried out for 6 hours a day, 5 days a week at exposure levels of 0, 20, 40, 80 or 160 ppm. The initial group size was 70 mice of each sex, of which 10 mice of each sex were allocated for sacrifice following 52 and 78 weeks of exposure. Due to increased mortality in female control mice terminal sacrifice took place during Week 98. Male mice were sacrificed as scheduled following 104 weeks of exposure. Samples of blood were removed from mice immediately after a typical exposure (Week 74) and analysed for styrene monomer and styrene oxide.