NTP Technical Report on Comparative Toxicity Studies of o-, m-, and p-Chloroaniline (CAS No. 95-51-2, 108-42-9, and 106-47-8) Administered by Gavage to F344/N Rats and B6C3F Mice

摘要

Chlorinated anilines are used as intermediates in the manufacture of dyes, drugs,and agricultural agents. In comparative 13-week studies conducted to determine the structure-toxicity relationships of o-, m-. and p-chloroaniline, groups of 10 male and 10 female F344/N rats and B6C3F1 mice were administered 0, 10, 20, 40,