NTP Technical Report on the Toxicity and Metabolism Studies of Chloral Hydrate211 (CAS No. 302-17-0) Administered by Gavage to F344/N Rats and B6C3F1 Mice

摘要

Chloral hydrate is widely used as a sedative and a hypnotic in pediatric211u001emedicine. It is also a byproduct of water chlorination. Chloral hydrate has been 211u001eshown to be genotoxic in numerous prokaryotic and eurkaryotic assay systems 211u001eincluding human lymphocytes in vitro. One of its metabolites, trichloroacetic 211u001eacid, has demonstrated hepatocarcinogenic activity in mice. Trichloroethylene and 211u001eperchloroethylene, both of which are metabolized to chloral hydrate, have been 211u001eshown to be carcinogenic in rats and/or mice. Because of this evidence of