Review of the Formaldehyde Assessment in the National Toxicology Program 12th Report on Carcinogens.

摘要

In 1981, The National Toxicology Program (NTP) first listed formaldehyde in the 2nd Report on Carcinogens (RoC) as reasonably anticipated to be a human carcinogen. In 2011, NTP upgraded the listing of formaldehyde in the 12th RoC to known to be a human carcinogen. Following the new listing, Congress directed the Department of Health and Human Services to arrange for the National Academy of Sciences (NAS) to independently review formaldehydes substance profile and listing in the 12th RoC (112th Congress, 1st Session; Public Law 112-74). This report presents the findings and conclusions of the committee formed in response to the congressional request. To address its statement of task, the committee first conducted a peer review of the formaldehyde substance profile and listing in the 12th RoC. It considered literature available to NTP up to the publication of the 12th RoC (that is, literature published by June 10, 2011). The committee then conducted an independent assessment of formaldehyde and made a listing recommendation using the RoC listing criteria. In its independent assessment, the committee examined evidence published both before and after the publication of the 12th RoC. It considered presentations heard during its open-session meeting, comments submitted from the general public, and abstracts presented during conferences. It reviewed reports published by other authoritative bodies, and it examined primary literature, reviews, and meta-analyses that were publicly available in the peerreviewed literature