Morbidity and Mortality Weekly Report, Volume 49, No. RR-6, June 9, 2000.Targeted Tuberculin Testing and Treatment of Latent Tuberculosis Infection

摘要

This statement provides new recommendations for targeted tuberculin testing andtreatment regimens for persons with latent tuberculosis infection (LTBI) and updates previously published guidelines. there has been interest in the development of shorter, rifampin-based regimens as alternatives to isoniazid for the treatment of LTBI. During the past decade, a series of studies of short-course treatment of LTBI in persons with human immunodeficiency virus (HIV) infection has been undertaken. The results of these trials have recently become available, and the in-depth analyses of these and prior studies of isoniazid form the scientific basis of the treatment guidelines presented in this report. In addition, many changes to previous recommendations regarding testing for and treatment of LTBI are presented.