Sperm Capture Using Aptamer Based Technology. Final Technical Report

摘要

The Denver Police Department Crime Laboratory has continued the collaboration with SomaLogic, Inc. (Boulder, Colorado) to identify and develop a DNA aptamer-based system for sperm binding, isolation and purification for DNA analysis in sexual assault cases. Over the last several years, a class of DNA aptamer molecules called SOMAmers (Slow Off-rate Modified Aptamers) have been identified which bind specifically to sperm heads and tails. Several SOMAmer candidates have been further selected with the ability to bind sperm under very stringent and selective conditions.