NTP Technical Report on Toxicology and Carcinogenesis Studies of Methylegenol(CAS No. 93-15-2) in F344/N Rats and B6C3f1 Mice (Gavage Studies)

摘要

Methyleugenol is used as a flavoring agent in jellies, baked goods, nonalcoholicbeverages, chewing gum, candy, pudding, relish, and ice cream. It is also used as a fragrance in perfumes, creams, lotion, detergents, and soaps. Methyleugenol has also been used as an insect attractant in eradication programs and as an anesthetic in rodents. Methyleugenol was nominated for testing because of its widespread use and because of its structural resemblance to safrole, a known carcinogen, and isosafrole and estragole. Male and female F344/N rats and B6C43F1 mice received methyl-cellulose by gavage for 14 weeks or 2 years. Genetic toxicology studies were conducted in Salmonella typhimurium, cultured Chinese hamster ovary cells, and mouse peripheral blood erythrocytes.