Utility of Biomarkers as Exposure and Dose Measures;Final rept

摘要

This study examined variation in the levels of biological measures of exposure to workplace contaminants. Although intra- and inter-individual differences have been characterized for a large number of airborne exposures across occupational groups, similar variation had not been investigated extensively for biological measures. A primary objective of this study was to compile a database of repeated biological measures so that the within- and between-worker sources of variability could be partitioned for as wide a range of biomarkers as possible. Following a review of the world's published literature, biological monitoring data were abstracted from 52 studies that examined workers' exposures to metals, solvents, polycyclic aromatic hydrocarbons, and pesticides. Forty-four percent of the studies also reported personal sampling results, which were compiled as well. Over 4,000 measurements collected on 577 workers in 55 workplaces are contained in the biological database, which represents a wide range of biomarkers collected in blood, urine, and exhaled air.