Importance of Being Cigar-Shaped. Modelling, Analysis and Simulation. (MAS)

摘要

The authors studied whether metabolic pathways with membrane-bound enzymes can give rise to significant concentration gradients in the cytosolic pathway components. They investigated this issue using a theoretical model for the phosphoenolpyruvate:glucose phosphotransferase system in E. coli, for which accurate measurements of the kinetic parameters are available. In this study we modeled an E. coli by a sphere. In reality E. coli is rod-like or rather cigar-shaped. In this paper we discuss the implementational aspects and the potenital implications of a more realistic geometry.