NIAID (National Institute of Allergy and Infectious Diseases) Topical Microbicide Strategic Plan

摘要

The HIV pandemic, more than 40 million people infected, 19.2 million of them women, predominantly through sexual intercourse has focused attention on sexually transmitted infections (STIs), both because HIV infection is a fatal STI and because other STIs are risk factors for sexual transmission of HIV. Without effective measures to prevent sexual transmission of HIV and other STIs, HIV incidence will continue to rise. In addition, STIs other than HIV cause significant morbidity and mortality, accounting for more than 17 billion dollars in costs annually in the United States alone. A consensus has emerged that safe, effective, accessible topical microbicides are needed to prevent sexually transmitted HIV infection as well as other STIs. Such products, foams, gels, creams, suppositories, etc. would be designed for intravaginal or intrarectal use where they would inactivate or block sexually transmitted pathogens such as HIV and other STIs.