Mechanisms of Particulate Toxicity: Health Effects in Susceptible Humans;Final rept

摘要

Particulate air pollution is an issue of global health importance, being a major component of air pollution, and having been associated with increased human cardiorespiratory morbidity and mortality. Individuals with asthma could be particularly susceptible to the respiratory health effects of particulate air pollution, due to the airway inflammation and hyper-reactivity components of the disease. This project was designed to test the hypothesis that airway inflammation would be increased, and spirometric pulmonary function (SPF) and heart rate variability (HRV), would be decreased as a function of a single particle exposure, and to a larger degree, as a function of a combined particle and 03 exposure and a serial particle exposure, compared to filter air exposure. This project consisted of two controlled human exposure experiments.