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Small Molecules and a Pharmacophore Model for Inhibition of Botulinum Toxin and Methods of Making and Using Thereof.

机译：用于抑制肉毒毒素的小分子和药效团模型及其制备和使用方法。

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摘要

The present invention generally relates to inhibitors of botulinum neurotoxin A metalloprotease activity.

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作者
Bavari, S.; Schmidt, J. J.; Burnett, J.; Gussio, R.;
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年度 2004
页码 1-36
总页数 36
原文格式 PDF
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关键词
Molecules; Clostridium botulinum; Toxins; Patent applications; Neurotoxins; Bacterial toxins; Inhibitors; Molecular biology; Pharmacophores; Botulinum toxin;

机译：分子;肉毒杆菌;毒素;专利申请;神经毒素;细菌毒素;抑制剂;分子生物学;药效团;肉毒杆菌毒素;

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1. Small molecule non-peptide inhibitors of botulinum neurotoxin serotype E: Structure-activity relationship and a pharmacophore model [J] . Kumar Gyanendra, Agarwal Rakhi, Swaminathan Subramanyam Bioorganic and medicinal chemistry . 2016,第18期

机译：肉毒杆菌神经毒素血清型E的小分子非肽抑制剂：构效关系和药效团模型
2. Multiple e-Pharmacophore modeling to identify a single molecule that could target both streptomycin and paromomycin binding sites for 30S ribosomal subunit inhibition [J] . Anju C. P., Subhramanian Sunitha, Sizochenko Natalia, Journal of Biomolecular Structure and Dynamics . 2019,第5a6期

机译：多种E-药物模型以鉴定单个分子，其可以针对30S核糖体亚基抑制的链霉素和偏霉素结合位点靶向链霉素和偏霉素结合位点
3. Long-term Effects of the Non-paralytic Botulinum Toxin a Molecule Bitox in a Migraine Animal Model [J] . Andreou A. P., AbuukarAbdullahi R., Lloyd J. O., Headache . 2018,第8期

机译：非瘫痪肉毒杆菌毒素在偏头痛动物模型中分子肉毒杆菌的长期影响
4. Clinical Use of Botulinum Toxin in Spasticity Case Description: Severe Adverse Effect with the Use of the Chinese Botulinum Toxin - Prosigne~R [C] . M. Sposito International Society of Physical and Rehabilitation Medicine . 2007

机译：骨髓蛋白在痉挛性案例中的临床应用案例描述：对使用中国肉毒杆菌毒素的严重不良影响 - ProSigne〜R
5. Metal ion-mediated inactivation and small molecule inhibition of the metalloprotease in botulinum neurotoxin A [D] . Feng, Minghao 2012

机译：金属离子介导的肉毒杆菌神经毒素A中金属蛋白酶的失活和小分子抑制
6. Correction: Kutlushina A. et al. Ligand-Based Pharmacophore Modeling Using Novel 3D Pharmacophore Signatures. Molecules 2018 23 3094 [O] . Alina Kutlushina, Aigul Khakimova, Timur Madzhidov, 2019

机译：校正：KutlushinaA.等。使用新型3D Pharmacophore签名的基于配体的Pharmacophore建模。分子2018233094
7. Pharmacophore Modeling using Site-Identification by Ligand Competitive Saturation (SILCS) Method with Multiple Probe Molecules [O] . Yu Wenbo, Raman E. Prabhu, Lakkaraju Sirish Kaushik, 2015

机译：使用配体竞争饱和（SILCS）方法与多个探针分子进行位点识别的药效团建模
8. Small Molecules and a Pharmacophore Model for Inhibition of Anthrax Lethal Factor. [R] . Bavari, S., Panhal, R. G., Hermone, A., 2004

机译：小分子和抑制炭疽致死因子的药效团模型。

Small Molecules and a Pharmacophore Model for Inhibition of Botulinum Toxin and Methods of Making and Using Thereof.

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