Inhibitors of Cellular Necrosis.

机译：细胞坏死的抑制剂。

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摘要

The present invention relates to compounds and pharmaceutical preparations and their use in therapy for preventing or treating trauma, ischemia, stroke and degenerative diseases associated with cell death. Methods and compositions of the invention are particularly useful for treating neurological disorders associated with cellular necrosis.

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Cuny, G. D.; Yuan, J.; Jagtap, P.; Degterev, A.;
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年度 2004
页码 1-59
总页数 59
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Necrosis; Cells(Biology); Patent applications; Inhibitors; Therapy; Pharmacology; Prevention; Medical treatment; Trauma; Ischemia; Stroke; Degenerative diseases; Cell death; Compositions; Methods; Nervous system diseases;

机译：坏死;细胞（生物学）;专利申请;抑制剂;治疗;药理学;预防;医学治疗;创伤;缺血;中风;退行性疾病;细胞死亡;组合物;方法;神经系统疾病;

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1. Real-time ultrasound imaging of irreversible electroporation in a porcine liver model adequately characterizes the zone of cellular necrosis. [J] . Schmidt CR, Shires P, Mootoo M HPB: the official journal of the International Hepato Pancreato Biliary Association . 2012,第2期

机译：猪肝脏模型中不可逆电穿孔的实时超声成像可以充分表征细胞坏死区域。
2. Loss of viability during freeze-thaw of intact and adherent human embryonic stem cells with conventional slow-cooling protocols is predominantly due to apoptosis rather than cellular necrosis. [J] . Heng BC, Ye CP, Liu H, Journal of biomedical science. . 2006,第3期

机译：用常规的慢冷方案冻融完整的和粘附的人类胚胎干细胞过程中的活力丧失主要是由于凋亡而不是细胞坏死。
3. Cellular and molecular derangements in acute tubular necrosis. [J] . Devarajan P Current opinion in pediatrics . 2005,第2期

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4. Cyclotides from Pombalia, Noisettia and Viola Genus: Discovery and Inhibitors of Cellular Migration [C] . Meri Emili F. Pinto, Jenny Najas Z. Garavito, Luma G. Magalhaes American Peptide Symposium . 2015

机译：来自Pombally，Noisettia和Viola属的循环苷：Cellular迁移的发现和抑制剂
5. A novel role for the apoptosis inhibitor ARC in suppressing death receptor-mediated necrosis. [D] . Kung, Gloria. 2013

机译：凋亡抑制剂ARC在抑制死亡受体介导的坏死中的新作用。
6. Cellular FLIP long isoform (cFLIPL)–IKKα interactions inhibit IRF7 activation representing a new cellular strategy to inhibit IFNα expression [O] . Lauren T. Gates-Tanzer, Joanna L. Shisler 2018

机译：细胞FLIP长亚型（cFLIPL）–IKKα相互作用抑制IRF7激活代表了抑制IFNα表达的新细胞策略
7. Faculty Opinions recommendation of Catalytic activity of the caspase-8-FLIP(L) complex inhibits RIPK3-dependent necrosis. [O] . Anne Voss 2020

机译：CASCOLY IPITIONS Caspase-8-翻转（L）复合物的催化活性的推荐抑制RIPK3依赖性坏死。

Inhibitors of Cellular Necrosis.

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