NTP Technical Report on the Toxicity Studies of 1,1,2,2-Tetrachloroethane (CAS No. 79-34-5) Administered in Microcapsules in Feed to F344/N Rats and B6C3F1 Mice

摘要

1,1,2,2-Tetrachloroethane is a solvent that was used in soil sterilization and as an ingredient in herbicides, insecticides, paints, varnishes, metal cleaners, and degreasers. Its production in the United States as an end-product ceased in the early 1990s. 1,1,2,2-Tetrachloroethane is currently used only as a chemical intermediate in the production of other chemicals. It was nominated for study because it was widely used and because it is found in hazardous waste sites and in surface water and groundwater. F344/N rats and B6C3F1 mice were administered 1,1,2,2-tetrachloroethane (at least 99% pure) in microcapsules in the feed for 15 days or 14 weeks. Animals were evaluated for clinical pathology, reproductive system effects, and histopathology. Genetic toxicity studies were conducted in vitro in Salmonella typhimurium, L5178Y mouse lymphoma cells, and Chinese hamster ovary cells and in vivo in Drosophila melanogaster and mouse peripheral blood erythrocytes.