Expansion of NK Cells and Therapeutic Uses Thereof.

机译：NK细胞的扩增及其治疗用途。

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The present invention relates to novel methods for preferentially activating and expanding NK cells. The methods utilize the stimulatory effects of IL-15 and CD137 ligand to preferentially expand and activate NK cells in a mixed cell culture comprising NK cells.

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Campana, D.; Imai, C.;
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年度 2005
页码 1-10
总页数 10
原文格式 PDF
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关键词
Cell cultures; Therapy; Patent applications; Ligands; Neoplasms; Lymphoma; Leukemia; Stem cells; Transplantation; Cytotoxicity; Methods; Natural killer(NK) cells;

机译：细胞培养;治疗;专利申请;配体;肿瘤;淋巴瘤;白血病;干细胞;移植;细胞毒性;方法;自然杀伤（NK）细胞;

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1. Highly efficient IL-21 and feeder cell-driven ex vivo expansion of human NK cells with therapeutic activity in a xenograft mouse model of melanoma [J] . Granzin Markus, Stojanovic Ana, Miller Matthias, Oncoimmunology. . 2016,第9期

机译：高效的IL-21和饲养细胞驱动的人NK细胞的离体膨胀，在黑发瘤的异种移植小鼠模型中具有治疗活性
2. The early expansion of anergic NKG2A pos/CD56 dim/CD16 neg natural killer represents a therapeutic target in haploidentical hematopoietic stem cell transplantation [J] . Alessandra Roberto, Clara Di Vito, Elisa Zaghi, Haematologica . 2018,第8期

机译：NKG2A pos / CD56 dim / CD16 neg 自然杀伤剂的早期扩增代表了单倍体造血干细胞移植的治疗目标。
3. Inhibition of T-cell activation in vitro in human peripheral blood mononuclear cells by pimecrolimus and glucocorticosteroids and combinations thereof. [J] . Winiski A, Wang S, Schwendinger B, Experimental dermatology . 2007,第8期

机译：吡美莫司和糖皮质激素及其组合在体外抑制人外周血单个核细胞中的T细胞活化。
4. Large-scale Expansion of Cells for Use as Therapeutic Agents [C] . Juan Melero-Martin, Shanmugapriya Santhalingam, Mohained Al-Rubeai General Meeting of European Society of Animal Cell Technology . 2007

机译：用于细胞的大规模扩张，用作治疗剂
5. New linkers and strategies for solid phase organic synthesis and their application to natural products synthesis and libraries thereof. Solid phase synthesis of HPE, epothilones, sarcodictyins, zearalenone and vancomycin [D] . Winssinger, Nicolas 2000

机译：固相有机合成的新接头和策略及其在天然产物合成及其文库中的应用。 HPE，埃博霉素，石co素，玉米赤霉烯酮和万古霉素的固相合成
6. Highly efficient IL-21 and feeder cell-driven ex vivo expansion of human NK cells with therapeutic activity in a xenograft mouse model of melanoma [O] . Markus Granzin, Ana Stojanovic, Matthias Miller, 2016

机译：在黑色素瘤异种移植小鼠模型中高效的IL-21和饲养细胞驱动的人NK细胞体外扩增具有治疗活性
7. Highly efficient IL-21 and feeder cell-driven ex vivo expansion of human NK cells with therapeutic activity in a xenograft mouse model of melanoma [O] . Markus Granzin, Ana Stojanovic, Matthias Miller, 2016

机译：高效的IL-21和饲养细胞驱动的人NK细胞的exvivo膨胀，具有在黑发瘤的异种移植小鼠模型中的治疗活性

Expansion of NK Cells and Therapeutic Uses Thereof.

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