Dermal Absorption of Cutting Fluid Mixtures;Final progress rept

摘要

This work has focused on understanding how cutting fluid additives, contaminants, and metal-working cleanser can influence the dermal disposition of potential skin irritants. Representatives of three commonly used classes of additives (emulsifier, lubricant, and biocide) were investigated in this study. The three representative additives, linear alkylbenzene sulfonate (LAS), sulfate ricinoleic acid (RA), and triazine, were used in the initial phases of this research answer these questions. Diffusion of these additives across skin and inert membranes was determined experimentally to help identify physicochemical and chemical-biological interactions when workers are exposed to similar complex cutting fluid formulations. Because triazine was shown to be more readily absorbed across skin, it was used as a chemical marker to further assess contaminant and cleanser effects on dermal absorption.