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AI-2 Compounds and Analogs Based on Salmonella Typhimurium LsrB Structure.

机译：aI-2基于鼠伤寒沙门氏菌LsrB结构的化合物和类似物。

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This invention relates to crystals comprising apo-LsrB and holo-LsrB. The structure of holo-LsrB identifies a tetrahydroxytetrahydrofuran derived from 4,5-dihydroxy-2,3-pentanedione (DPD) as the active autoinducer-2 (AI-2) molecule in Salmonella typhimurium. The X-ray crystallographic data can be used in a drug discovery method. Additionally the invention provides AI-2 analogs based on this discovery as well as pharmaceutical compositions containing those analogs.

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Miller, S. T.; Xavier, K. B.; Taga, M. E.; Campagna, S. R.; Semmelhack, M. F.;
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年度 2005
页码 1-29
总页数 29
原文格式 PDF
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Patent applications; Crystals; Bacteria; Pharmaceutical compositions; Analogs; Microorganisms; Salmonella typhimurium; AI-2 compounds; Apo-LsrB; Holo-LsrB; Tetrahydroxytetrahydrofuran; X-ray crystallographic data; Autoinducers;

机译：专利申请;晶体;细菌;药物组合物;类似物;微生物;鼠伤寒沙门氏菌; aI-2化合物; apo-LsrB; Holo-LsrB;四羟基四氢呋喃; X射线晶体学数据;自动诱导剂;

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专利

1. The LuxS-dependent autoinducer AI-2 controls the expression of an ABC transporter that functions in AI-2 uptake in Salmonella typhimurium. [J] . Taga ME, Semmelhack JL, Bassler BL Molecular Microbiology . 2001 ,第3期

机译：依赖LuxS的自诱导物AI-2控制在鼠伤寒沙门氏菌中AI-2摄取中起作用的ABC转运蛋白的表达。
2. Inhibitory effects of lactic and malic organic acids on autoinducer type 2 (AI-2) quorum sensing of Escherichia coli O157:H7 and Salmonella Typhimurium [J] . Almasoud Ahmad, Hettiarachchy Navam, Rayaprolu Srinivas, LWT-Food Science & Technology . 2016 ,第Null期

机译：乳酸和苹果酸对大肠杆菌O157：H7和鼠伤寒沙门氏菌自诱导型2（AI-2）群体感应的抑制作用
3. Rapid and simple colorimetric method for the quantification of AI-2 produced from Salmonella Typhimurium. [J] . Siriluck Wattanavanitchakorn, Cheunjit Prakitchaiwattana, Patchanita Thamyongkit Journal of Microbiological Methods . 2014 ,第Null期

机译：快速简便的比色法定量鼠伤寒沙门氏菌产生的AI-2。
4. A simple structured model for growth and AI-2 mediated cell-cell communication of Salmonella Typhimurium [C] . Astrid M. Cappuyns, Kristel Bernaerts, Sigrid C. De Keersmaecker, Mediterranean Conference on Control Automation . 2008

机译：一种简单的结构化模型，生长和AI-2介导的沙门氏菌细胞间通信
5. Analysis of the mechanisms for uronate isomerase from Escherichia coli, cobyrinic acid a,c-diamide synthetase from Salmonella typhimurium, and cobyric acid synthetase from Salmonella typhimurium [D] . Williams, Lakenya 2007

机译：大肠杆菌尿酸异构酶，鼠伤寒沙门氏菌中的bybyrinic酸，α-二酰胺合成酶和鼠伤寒沙门氏菌中的bybyric酸合成酶的机理分析
6. A macrophage-based screen identifies antibacterial compounds selective for intracellular Salmonella Typhimurium [O] . Michael J. Ellis, Caressa N. Tsai, Jarrod W. Johnson, -1

机译：基于巨噬细胞的屏幕可识别对细胞内鼠伤寒沙门氏菌具有选择性的抗菌化合物
7. Influence of autoinducer 2 (AI-2) and AI-2 inhibitors generated from processed poultry on virulence and growth of Salmonella enterica serovar Typhimurium [O] . Widmer Kenneth Walter 2009

机译：加工家禽产生的自诱导物2（AI-2）和AI-2抑制剂对肠炎沙门氏菌血清鼠伤寒毒力和生长的影响
8. Carcinogenic N-Hydroxylaminopurine Derivatives Do Not Act as Base Analog Mutagens in 'Salmonella typhimurium' [R] . McCartney, M. , McCoy, E. C. , Rosenkranz, H. S. , 1985

机译：致癌的N-羟基氨基嘌呤衍生物在“鼠伤寒沙门氏菌”中不起基础类似物致突变物的作用

AI-2 Compounds and Analogs Based on Salmonella Typhimurium LsrB Structure.

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