Methods for Synthesizing 2-Chloro-9(2- Deoxy-2-Fluoro-Beta-D- Arabinofuranosyl) -9H-Purin-6-Amine.

摘要

2-Chloro-9-(2-deoxy- 2-fluoro-beta- D-arabinofuranosyl) -9H-purin-6-amine is synthesized by reacting a 2-chloro-6-substituted purine with a protected and activated 2-deoxy-2-fluoro- D-arabinofiranose; and reactingwith a base such as ammonia to provide 2-chloro-9-(2-deoxy-2-fluoro-beta- D-arabinofuranosyl) -9H-purin-6-amine.When the purine reactant is substituted in the 6 position with a halogen, a reaction step with an alkoxide is carried out prior to the reaction with ammonia.