Methods for Modulation Cell Survival by Modulation BCL-XL Protein Level.

摘要

Methods for protecting a T cell from cell death are described. The methods involve contacting the T cell with an agent which augments the bcl-X(sub L) protein level in the T cell such that it is protected from cell death. The invention further pertains to methods for increasing the susceptibility of a T cell to cell death, comprising contacting the T cell with at least one agent which decreases bcl-X(sub L) protein level in the T cell. Both in vivo and in vitro methods are described.