Responsiveness Summary for the Avian Egg Injection Study Plan. Hudson River Natural Resource Damage Assessment. Final, June 5, 2006.

摘要

The harmful effects of PCBs are well documented. Widespread concern over their adverse effects on human health and the environment led to legislation under the Toxic Substances Control Act (TSCA) in the 1970s which resulted in banning their production and use in nearly all circumstances. In humans, PCB exposure has been associated with developmental effects and neurobehavioral deficits in children born to mothers exposed to dietary sources of PCBs during pregnancy (Fein et al. 1984; Jacobson et al. 1985, 1990a, b). Occupational exposure to PCBs has also been associated with increased cancer risk and other effects on the cardiovascular, hepatic, immune, musculoskeletal, endocrine, gastrointestinal, and dermal systems (reviewed by Johnson et al., 1999, for the U.S. Department of Health and Human Services). The adverse effects of PCBs on developing chicks are also well documented and include mortality, physical deformities of the heart, eyes, limbs and beak, brain asymmetry, liver lesions, and edema, as well as aberrant reproductive behavior.