Diagnosis and Management of Ductal Carcinoma in Situ (DCIS). Evidence Report/Technology Assessment Number 185

摘要

Objectives: Systematic synthesis of the published evidence about incidence, risk factors, and management options for women with ductal carcinoma in situ (DCIS) of the breast. Data Sources: Original epidemiologic studies were sought from several databases to identity articles published in English between 1970 and January 31, 2009. Review Methods: Incidence of DCIS in the general population and among women at greater risk of breast cancer and patient outcomes after diagnostic magnetic resonance imaging (MRI) or sentinel lymph node biopsy (SLNB) were abstracted into the developed standardized form. Patient outcomes after breast conserving surgery with or without adjuvant radio or chemotherapy or after mastectomy were compared from randomized controlled clinical trials (RCTs) and observational studies.